Recent publications
2015
Malho, J-M. Arola, S., Laaksonen, P., Szilvay, G., Ikkala, O., Linder, M.B., (2015) Modular Architecture of Protein Binding Units for Designing Properties of Cellulose Nanomaterials Angew. Chem. Int. Ed. 54, Free dowload at http://dx.doi.org/10.1002/anie.201505980.
Gabryelczyk, B., Szilvay, G., Singh, V., Mikkliä, J., Kostiainen, M.A., Koskinen, J., and Linder, M.B. (2015) Engineering of the function of diamond-like carbon binding peptides through structural design, Biomacromolecules, 16 (2) 476-482
Lienemann, M., Gruner, M., Paanaen, A., Siika-aho, M., Linder, MB (2015) Charge-Based Engineering of Hydrophobin HFBI: Effect on Interfacial Assembly and Interactions, Biomacromolecules, 16 (4) 1283-1292
Gazzera. L., Corti, C., Pirrie. L. Paananen. A., Monfredini, A., Cavallo, G., Bettini, S., Giancane. G., Valli. L. Linder, M.B., Resnati, G., Milani, R., and Metrangolo, P. (2015) Hydrophobin as a nanolayer primer that enables the fluorinated coating of poorly reactive polymer surfaces, Adv. Mater. Interfaces 2015, 1500170
Ridout, J.M., Paananen, A., Mamode, A., Linder, MB.; Wilde, PJ, (2015) Interaction of transglutaminase with adsorbed and spread films of β-casein and к-casein , Colloids and Surfaces B: Biointerfaces doi:10.1016/j.colsurfb.2015.01.045
Ridout, J.M., Paananen, A., Mamode, A., Linder, MB.; Wilde, PJ, (2015) Interaction of transglutaminase with adsorbed and spread films of β-casein and к-casein , Colloids and Surfaces B: Biointerfaces doi:10.1016/j.colsurfb.2015.01.045
Malho, J-M., Ouellet-Plamondon, C., Rüggeberg, M., Laaksonen, P., Ikkala, O., Burgert, I., Linder, M.B. (2015) Enhanced Plastic Deformations of Nanopaper by Adsorbed Moisture and Protein Mediated Interactions. Biomcromolecules, 16, 311-318.
Yotprayoonsak, P., Szilvay, G. R., Laaksonen, P., Linder, M. B., & Ahlskog, M. (2015). The Effect of Hydrophobin Protein on Conductive Properties of Carbon Nanotube Field-Effect Transistors: First Study on Sensing Mechanism. Journal of Nanoscience and Nanotechnology, 15(3), 2079-2087.
2014
Magarkar, A., Mele, N., Abdel-Rahman, N., Butcher, S., Torkkeli, M., Serimaa, R., ... & Bunker, A. (2014). Hydrophobin Film Structure for HFBI and HFBII and Mechanism for Accelerated Film Formation. PLoS computational biology, 10(7), e1003745.
Jani-Markus Malho, Claudiane Ouellet-Plamondon, Markus Rüggeberg, Päivi Laaksonen, Olli Ikkala, Ingo Burgert, and Markus B. Linder (2014) Enhanced Plastic Deformations of Nanofibrillated Cellulose Film by Adsorbed Moisture and Protein-Mediated Interactions.Biomacromolecules
Jani-Markus Malho,Hanna Heinonen, Inkeri Kontro, Ngesa E. Mushi, Ritva Serimaa, Hans-Peter Hentze, Markus B. Linder and Géza R. Szilvay (2014). Formation of ceramophilic chitin and biohybrid materials enabled by a genetically engineered bifunctional protein. Chem. Commun., 2014,50, 7348-7351
T. J. Hakala, P. Laaksonen,, A. Helle, M. B. Linder, and K. Holmberg(2014). Effect of operational conditions and environment on lubricity of hydrophobins in water based lubrication systems. Tribology - Materials, Surfaces & Interfaces.
Katri Kurppaa, Vesa P. Hytönen, Tiina Nakari-Setälä, Markku S. Kulomaa, Markus B. Linder(2014). Molecular engineering of avidin and hydrophobin for functional self-assembling interfaces . Elsevier volume120, pages 102-109.
Hanna Heinonen, Päivi Laaksonen, Markus B. Linder, Hans-Peter Hentze (2014). Engineered Hydrophobin for Biomimetic Mineralization of Functional Calcium Carbonate Microparticles. Journal of Biomaterials and Nanobiotechnology, Vol. 5 No. 1, 2014, pp. 1-7.
Timo J. Hakala, Vesa Saikko, Suvi Arola, Tiina Ahlroos, Aino Helle, Petri Kuosmanen,Kenneth Holmberg, Markus B. Linder, Päivi Laaksonen (2014). Structural characterization and tribological evaluation of quince seed mucilage. Elseviervolume 77, page 24-31.
2013
Arola S., Malho J.M., Laaksonen P., Lille M., Linder M.B. (2013) The role of hemicellulose in nanofibrillated cellulose networks. Soft Matter 9, 1319-1326
Lienemann, M., Gandier, J-A., Joensuu, J.J., Iwanaga, A. Takatsuji, Y., Haruyama, T., Master, E., Tenkanen, M., and Linder, M.B. (2013) Structure – function relationships in hydrophobins: Probing the role of charged side chains. Applied and Environmental Microbiology
Gabryelczyk, B., Szilvay, G., Salomäki, M., Laaksonen, P., and Linder, M.B. (2013) Selection and characterization of peptides binding to diamond-like carbon. Colloids and Surfaces B: Biointerfaces, 110, 66-73
Olga Krivosheeva, Andra Dėdinaitė, Markus B. Linder, Robert D. Tilton, and Per M. Claesson (2013). Kinetic and Equilibrium Aspects of Adsorption and Desorption of Class II Hydrophobins HFBI and HFBII at Silicon Oxynitride/Water and Air/Water Interfaces..Langmuir 2013 29 (8), 2683-2691.
Michael Lienemann , Julie-Anne Gandier , Jussi J. Joensuu , Atsushi Iwanaga , Yoshiyuki Takatsuji , Tetsuya Haruyama , Emma Master , Maija Tenkanen and Markus B. Linder (2013) . Structure-Function Relationships in Hydrophobins: Probing the Role of Charged Side Chains.American society for microbiology.
Hanna Valo, Suvi Arola, Päivi Laaksonen, Mika Torkkeli, Leena Peltonen, Markus B. Linder, Ritva Serimaa, Shigenori Kuga, Jouni Hirvonen, Timo Laaksonen(2013). Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels.Elsvier volume50, issue1. Page 69-77
Arja Paananen, Dilek Ercili-Cura, Markku Saloheimo, Raija Lantto and Markus B. Linder (2013). Directing enzymatic cross-linking activity to the air–water interface by a fusion protein approach . Soft Matter , Issue 5.
Yoshiyuki Takatsuji, Ryota Yamasaki, Atsushi Iwanaga, Michael Lienemann, Markus B. Linder, Tetsuya Haruyama(2013). Solid-support immobilization of a “swing” fusion protein for enhanced glucose oxidase catalytic activity.Elsevier, volume 112, page 186-191.
Ruzica Kolakovic, Leena Peltonen, Antti Laukkanen, Maarit Hellman, Päivi Laaksonen, Markus B. Linder, Jouni Hirvonen, Timo Laaksonen(2013). Evaluation of drug interactions with nanofibrillar cellulose. Elsevier, volume 85, issue 3, pages 1238-1244.
2012
Malho J-M., Laaksonen P., Walther A., Ikkala O., Linder M.B. (2012) Facile Method for Stiff, Tough and Strong Nanocomposites by Direct Exfoliation of Graphene into Native Nanocellulose Matrix. Biomacromolecules 13, 4, 1093–1099
Laaksonen P., Szilvay G., Linder M.B. (2012) Genetic engineering in biomimetic composites. Trends in Biotechnology 30, 4, 191-197
Sarlin, T., Kivioja, T., Kalkkinen, N., Linder, M. B., & Nakari‐Setälä, T. (2012). Identification and characterization of gushing‐active hydrophobins from Fusarium graminearum and related species. Journal of basic microbiology, 52(2), 184-194
Sarparanta, M., Bimbo, L. M., Rytkönen, J., Mäkilä, E., Laaksonen, T. J., Markus B. Linder, Laaksonen, P., ... & Airaksinen, A. J. (2012). Intravenous delivery of hydrophobin-functionalized porous silicon nanoparticles: stability, plasma protein adsorption and biodistribution. Molecular pharmaceutics, 9(3), 654-663.
Sarparanta, Mirkka P., Luis M. Bimbo, Ermei M. Mäkilä, Jarno J. Salonen, Päivi H. Laaksonen, A. M. Helariutta, Markus B. Linder (2012). The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems. Biomaterials 33, no. 11. 3353-3362.
Bimbo, Luis M., Mirkka Sarparanta, Ermei Mäkilä, Timo Laaksonen, Päivi Laaksonen, Jarno Salonen, Markus B. Linder, Jouni Hirvonen, Anu J. Airaksinen, and Hélder A. Santos (2012). Cellular interactions of surface modified nanoporous silicon particles.Nanoscale 4, no. 10 3184-3192.
Arola, S., Tammelin, T., Setälä, H., Tullila, A., & Linder, M. B. (2012). Immobilization–Stabilization of Proteins on Nanofibrillated Cellulose Derivatives and Their Bioactive Film Formation. Biomacromolecules, 13(3), 594-603.
Laaksonen, P., Szilvay, G. R., & Linder, M. B. (2012). Genetic engineering in biomimetic composites. Trends in biotechnology, 30(4), 191-197
Joensuu, J. J., Conley, A. J., Linder, M. B., & Menassa, R. (2012). Bioseparation of recombinant proteins from plant extract with hydrophobin fusion technology. In Recombinant Gene Expression (pp. 527-534). Humana Press.
Schulz, A., Fioroni, M., Linder, M. B., Nessel, A., Bocola, M., Subkowski, T., ... & Rodríguez-Ropero, F. (2012). Exploring the mineralization of hydrophobins at a liquid interface. Soft Matter, 8(44), 11343-11352
2011
Laaksonen P., Walther A., Malho J-M., Kainlauri M., Ikkala O., Linder M.B. (2011) Genetic Engineering of Biomimetic Nanocomposites Using Diblock Proteins, Graphene and Nanofibrillated Cellulose. Angewandte Chemie International Edition 50, 37, 8688–8691
Varjonen S, Laaksonen P., Paananen A., Valo H., Hähl H., Laaksonen T., Linder M.B. (2011) Self-Assembly of Cellulose Nanofibrils by Genetically Engineered Fusion Proteins. Soft Matter 7, 6, 2402-2411
Laaksonen, P., Walther, A., Malho, J. M., Kainlauri, M., Ikkala, O., & Linder, M. B. (2011). Genetic engineering of biomimetic nanocomposites: diblock proteins, graphene, and nanofibrillated cellulose. Angewandte Chemie International Edition, 50(37), 8688-8691.
Díez, I., Eronen, P., Österberg, M., Linder, M. B., Ikkala, O., & Ras, R. H. (2011). Functionalization of nanofibrillated cellulose with silver nanoclusters: Fluorescence and antibacterial activity. Macromolecular bioscience, 11(9), 1185-1191.
Bimbo, L. M., Mäkilä, E., Raula, J., Laaksonen, T., Laaksonen, P., Strommer, K., Linder, M. B., ... & Santos, H. A. (2011). Functional hydrophobin-coating of thermally hydrocarbonized porous silicon microparticles. Biomaterials, 32(34), 9089-9099.
Suchy, M., Linder, M. B., Tammelin, T., Campbell, J. M., Vuorinen, T., & Kontturi, E. (2011). Quantitative assessment of the enzymatic degradation of amorphous cellulose by using a quartz crystal microbalance with dissipation monitoring. Langmuir, 27(14), 8819-8828.
Iwanaga, A., Asakawa, H., Fukuma, T., Nakamichi, M., Shigematsu, S., Linder, M. B., & Haruyama, T. (2011). Ordered nano-structure of a stamped self-organized protein layer on a HOPG surface using a HFB carrier. Colloids and Surfaces B: Biointerfaces, 84(2), 395-399.
Ahlroos, T., Hakala, T. J., Helle, A., Linder, M. B., Holmberg, K., Mahlberg, R., ... & Varjus, S. (2011). Biomimetic approach to water lubrication with biomolecular additives. Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, 1350650111406635.
2010 & older
Laaksonen P., Kainlauri M., Laaksonen T., Shchepetov A. Jiang H., Ahopelto J., Linder M.B. (2010) Interfacial Engineering by Proteins - Exfoliation and Functionalization of Graphene by Hydrophobins. Angewandte Chemie International Edition 49, 29, 4946 –4949
Joensuu, J. J., Conley, A. J., Lienemann, M., Brandle, J. E., Linder, M. B., & Menassa, R. (2010). Hydrophobin fusions for high-level transient protein expression and purification in Nicotiana benthamiana. Plant physiology, 152(2), 622-633.
Valo, H. K., Laaksonen, P. H., Peltonen, L. J., Linder, M. B., Hirvonen, J. T., & Laaksonen, T. J. (2010). Multifunctional hydrophobin: toward functional coatings for drug nanoparticles. ACS nano, 4(3), 1750-1758.
Wang, Z., Lienemann, M., Qiau, M., & Linder, M. B. (2010). Mechanisms of protein adhesion on surface films of hydrophobin. Langmuir, 26(11), 8491-8496.
Wang, Z., Huang, Y., Li, S., Xu, H., Linder, M. B., & Qiao, M. (2010). Hydrophilic modification of polystyrene with hydrophobin for time-resolved immunofluorometric assay. Biosensors and Bioelectronics, 26(3), 1074-1079.
Linder, M. B. (2009). Hydrophobins: proteins that self assemble at interfaces. Current Opinion in Colloid & Interface Science, 14(5), 356-363.
Laaksonen, P., Kivioja, J., Paananen, A., Kainlauri, M., Kontturi, K., Ahopelto, J., & Linder, M. B. (2009). Selective nanopatterning using citrate-stabilized Au nanoparticles and cystein-modified amphiphilic protein. Langmuir, 25(9), 5185-519
Asakawa, H., Tahara, S., Nakamichi, M., Takehara, K., Ikeno, S., Linder, M. B., & Haruyama, T. (2009). The amphiphilic protein HFBII as a genetically taggable molecular carrier for the formation of a self-organized functional protein layer on a solid surface. Langmuir, 25(16), 8841-8844.
Partanen, R., Paananen, A., Forssell, P., Linder, M. B., Lille, M., Buchert, J., & Lantto, R. (2009). Effect of transglutaminase-induced cross-linking of sodium caseinate on the properties of equilibrated interfaces and foams. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 344(1), 79-85.
Kivioja, J. M., Kurppa, K., Kainlauri, M., Linder, M. B., & Ahopelto, J. (2009). Electrical transport through ordered self-assembled protein monolayer measured by constant force conductive atomic force microscopy. Applied Physics Letters, 94(18), 183901.
Derda, M., Winiecka-Krusnell, J., Linder, M. B., & Linder, E. (2009). Labeled Trichoderma reesei Cellulase as a Marker for Acanthamoeba Cyst Wall Cellulose in Infected Tissues. Applied and environmental microbiology, 75(21), 6827-6830.
Kisko, K., Szilvay, G. R., Vuorimaa, E., Lemmetyinen, H., Linder, M. B., Torkkeli, M., & Serimaa, R. (2008). Self-assembled films of hydrophobin proteins HFBI and HFBII studied in situ at the air/water interface. Langmuir, 25(3), 1612-1619.
Kisko, K., Szilvay, G. R., Vainio, U., Linder, M. B., & Serimaa, R. (2008). Interactions of hydrophobin proteins in solution studied by small-angle X-ray scattering. Biophysical journal, 94(1), 198-206.
Yu, L., Zhang, B., Szilvay, G. R., Sun, R., Jänis, J., Wang, Z., ... & Qiao, M. (2008). Protein HGFI from the edible mushroom Grifola frondosa is a novel 8 kDa class I hydrophobin that forms rodlets in compressed monolayers. Microbiology, 154(6), 1677-1685.
Lahtinen, T., Linder, M. B., Nakari-Setälä, T., & Oker-Blom, C. (2008). Hydrophobin (HFBI): A potential fusion partner for one-step purification of recombinant proteins from insect cells. Protein expression and purification, 59(1), 18-24.
Szilvay, G. R., Paananen, A., Laurikainen, K., Vuorimaa, E., Lemmetyinen, H., Peltonen, J., & Linder, M. B. (2007). Self-assembled hydrophobin protein films at the air-water interface: structural analysis and molecular engineering. Biochemistry, 46(9), 2345-2354.
Kurppa, K., Jiang, H., Szilvay, G. R., Nasibulin, A. G., Kauppinen, E. I., & Linder, M. B. (2007). Controlled Hybrid Nanostructures through Protein‐Mediated Noncovalent Functionalization of Carbon Nanotubes. Angewandte Chemie, 119(34), 6566-6569.
Kostiainen, M. A., Szilvay, G. R., Lehtinen, J., Smith, D. K., Linder, M. B., Urtti, A., & Ikkala, O. (2007). Precisely defined protein–polymer conjugates: construction of synthetic DNA binding domains on proteins by using multivalent dendrons. Acs Nano, 1(2), 103-113.
Kallio, J. M., Linder, M. B., & Rouvinen, J. (2007). Crystal structures of hydrophobin HFBII in the presence of detergent implicate the formation of fibrils and monolayer films. Journal of Biological Chemistry, 282(39), 28733-28739.
Voutilainen, S. P., Boer, H., Linder, M. B., Puranen, T., Rouvinen, J., Vehmaanperä, J., & Koivula, A. (2007). Heterologous expression of< i> Melanocarpus albomyces</i> cellobiohydrolase Cel7B, and random mutagenesis to improve its thermostability. Enzyme and microbial technology, 41(3), 234-243.
Szilvay, G. R., Kisko, K., Serimaa, R., & Linder, M. B. (2007). The relation between solution association and surface activity of the hydrophobin HFBI from< i> Trichoderma reesei</i>. FEBS letters, 581(14), 2721-2726.
Andberg, M., Jäntti, J., Heilimo, S., Pihkala, P., Paananen, A., Koskinen, A. M., ... & Linder, M. B. (2007). Cleavage of recombinant proteins at poly‐His sequences by Co (II) and Cu (II). Protein science, 16(8), 1751-1761.
Kisko, K., Szilvay, G. R., Vuorimaa, E., Lemmetyinen, H., Linder, M. B., Torkkeli, M., & Serimaa, R. (2007). Self-assembled films of hydrophobin protein HFBIII from Trichoderma reesei. Journal of Applied Crystallography, 40, s355-s360.
Ras, R. H., Ruotsalainen, T., Laurikainen, K., Linder, M. B., & Ikkala, O. (2007). Hollow nanoparticle nanotubes with a nanoscale brick wall structure of clay mineral platelets. Chemical Communications, (13), 1366-1368.
Kostiainen, M. A., Szilvay, G. R., Smith, D. K., Linder, M. B., & Ikkala, O. (2006). Multivalent Dendrons for High‐Affinity Adhesion of Proteins to DNA. Angewandte Chemie International Edition, 45(21), 3538-3542.
Szilvay, G. R., Nakari-Setälä, T., & Linder, M. B. (2006). Behavior of Trichoderma reesei hydrophobins in solution: interactions, dynamics, and multimer formation. Biochemistry, 45(28), 8590-8598.
Linder, M. B., Szilvay, G. R., Nakari‐Setälä, T., & Penttilä, M. E. (2005). Hydrophobins: the protein‐amphiphiles of filamentous fungi. FEMS microbiology reviews, 29(5), 877-896.
Hakanpää, J., Paananen, A., Askolin, S., Nakari-Setälä, T., Parkkinen, T., Penttilä, M., ... & Rouvinen, J. (2004). Atomic resolution structure of the HFBII hydrophobin, a self-assembling amphiphile. Journal of Biological Chemistry, 279(1), 534-539.
Linder, M. B., Qiao, M., Laumen, F., Selber, K., Hyytiä, T., Nakari-Setälä, T., & Penttilä, M. E. (2004). Efficient purification of recombinant proteins using hydrophobins as tags in surfactant-based two-phase systems. Biochemistry, 43(37), 11873-11882.
Paananen, A., Vuorimaa, E., Torkkeli, M., Penttilä, M., Kauranen, M., Ikkala, O., ... & Linder, M. B. (2003). Structural hierarchy in molecular films of two class II hydrophobins. Biochemistry, 42(18), 5253-5258.
Lehtiö, J., Sugiyama, J., Gustavsson, M., Fransson, L., Linder, M., & Teeri, T. T. (2003). The binding specificity and affinity determinants of family 1 and family 3 cellulose binding modules. Proceedings of the National Academy of Sciences, 100(2), 484-489.
Linder, M., Szilvay, G. R., Nakari‐Setälä, T., Söderlund, H., & Penttilä, M. (2002). Surface adhesion of fusion proteins containing the hydrophobins HFBI and HFBII from Trichoderma reesei. Protein science, 11(9), 2257-2266.
Torkkeli, M., Serimaa, R., Ikkala, O., & Linder, M. (2002). Aggregation and Self-Assembly of Hydrophobins from< i> Trichoderma reesei</i>: Low-Resolution Structural Models. Biophysical journal, 83(4), 2240-2247.
Linder, M., Selber, K., Nakari-Setälä, T., Qiao, M., Kula, M. R., & Penttilä, M. (2001). The Hydrophobins HFBI and HFBII from Trichoderma r eesei Showing Efficient Interactions with Nonionic Surfactants in Aqueous Two-Phase Systems. Biomacromolecules, 2(2), 511-517.
Palonen, H., Tenkanen, M., & Linder, M. (1999). Dynamic interaction of Trichoderma reesei cellobiohydrolases Cel6A and Cel7A and cellulose at equilibrium and during hydrolysis. Applied and environmental microbiology, 65(12), 5229-5233.
Carrard, G., & Linder, M. (1999). Widely different off rates of two closely related cellulose‐binding domains from Trichoderma reesei. European journal of biochemistry, 262(3), 637-643.
Mattinen, M. L., Linder, M., Drakenberg, T., & Annila, A. (1998). Solution structure of the cellulose‐binding domain of endoglucanase I from Trichoderma reesei and its interaction with cello‐oligosaccharides. European journal of biochemistry, 256(2), 279-286.
Linder, M., & Teeri, T. T. (1997). The roles and function of cellulose-binding domains. Journal of Biotechnology, 57(1), 15-28.
Mattinen, M. L., Kontteli, M., Kerovuo, J., Drakenberg, T., Annila, A., Linder, M., ... & Lindeberg, G. (1997). Three‐dimensional structures of three engineered cellulose‐binding domains of cellobiohydrolase I from Trichoderma reesei. Protein science, 6(2), 294-303.
Linder, M., & Teeri, T. T. (1996). The cellulose-binding domain of the major cellobiohydrolase of Trichoderma reesei exhibits true reversibility and a high exchange rate on crystalline cellulose. Proceedings of the National Academy of Sciences, 93(22), 12251-12255.
Linder, M., Salovuori, I., Ruohonen, L., & Teeri, T. T. (1996). Characterization of a double cellulose-binding domain Synergistic high affinity binding to crystalline cellulose. Journal of Biological Chemistry, 271(35), 21268-21272.
Linder, M., Lindeberg, G., Reinikainen, T., Teeri, T. T., & Pettersson, G. (1995). The difference in affinity between two fungal cellulose-binding domains is dominated by a single amino acid substitution. FEBS letters, 372(1), 96-98.
Linder, M., Mattinen, M. L., Kontteli, M., Lindeberg, G., Ståhlberg, J., Drakenberg, T., ... & Annila, A. (1995). Identification of functionally important amino acids in the cellulose‐binding domain of Trichoderma reesei cellobiohydrolase I. Protein Science, 4(6), 1056-1064.